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Summary by City
| POPULATION BY CITY |
| | 1960 | 1970 | 1980 | 1990 | 2000 |
| Adrian | 258 | 228 | 222 | 248 | 159 |
| Amarillo | 137,969 | 127,010 | 149,230 | 157,615 | 173,627 |
| Bishop Hills | N/A | N/A | N/A | N/A | 210 |
| Booker | 817 | 904 | 1,219 | 1,259 | 1,315 |
| Borger | 20,911 | 14,195 | 15,837 | 15,675 | 14,302 |
| Bovina | 1,029 | 1,428 | 1,499 | 1,549 | 1,874 |
| Cactus | N/A | 644 | 898 | 1,529 | 2,538 |
| Canadian | 2,239 | 2,292 | 3,491 | 2,420 | 2,233 |
| Canyon | 5,864 | 8,333 | 10,724 | 11,365 | 12,875 |
| Channing | 351 | 336 | 304 | 262 | 356 |
| Childress | 6,399 | 5,408 | 5,817 | 5,046 | 6,778 |
| Clarendon | 2,172 | 1,974 | 2,220 | 2,043 | 1,974 |
| Claude | 895 | 992 | 1,112 | 1,231 | 1,313 |
| Dalhart | 5,160 | 5,705 | 6,854 | 6,240 | 7,237 |
| Darrouzett | 375 | 396 | 444 | 370 | 303 |
| Dimmitt | 2,935 | 4,327 | 5,019 | 4,403 | 4,375 |
| Dodson | 308 | 239 | 185 | 129 | 115 |
| Dumas | 8,477 | 9,771 | 12,194 | 12,871 | 13,747 |
| Estelline | 346 | 301 | 258 | 177 | 168 |
| Farwell | 1,009 | 1,185 | 1,354 | 1,373 | 1,364 |
| Follett | 466 | 522 | 547 | 429 | 412 |
| Friona | 2,048 | 3,111 | 3,809 | 3,688 | 3,854 |
| Fritch | 1,617 | 1,778 | 2,299 | 2,335 | 2,235 |
| Groom | 679 | 808 | 736 | 603 | 587 |
| Gruver | 1,030 | 1,265 | 1,216 | 1,172 | 1,162 |
| Happy | 624 | 672 | 674 | 579 | 647 |
| Hart | 577 | 839 | 1,008 | 1,221 | 1,198 |
| Hartley CDP | N/A | N/A | N/A | N/A | 441 |
| Hedley | 494 | 439 | 380 | 415 | 379 |
| Hereford | 7,652 | 13,414 | 15,853 | 14,745 | 14,597 |
| Higgins | 711 | 582 | 702 | 451 | 425 |
| Howardwick | N/A | N/A | 165 | 205 | 437 |
| Kress | 438 | 578 | 783 | 753 | 826 |
| Lake Tanglewood | N/A | N/A | 485 | 634 | 825 |
| Lakeview | 219 | 214 | 244 | 195 | 152 |
| Lefors | 864 | 816 | 829 | 647 | 559 |
| Lipscomb CDP | N/A | N/A | N/A | N/A | 44 |
| McLean | 1,330 | 1,183 | 1,160 | 858 | 830 |
| Memphis | 3,332 | 3,227 | 3,352 | 2,451 | 2,479 |
| Miami | 656 | 611 | 813 | 679 | 588 |
| Mobeetie | N/A | N/A | 291 | 169 | 107 |
| Morse | N/A | N/A | N/A | N/A | 172 |
| Nazareth | N/A | N/A | 299 | 298 | 356 |
| Palisades Village | N/A | N/A | N/A | N/A | 352 |
| Pampa | 24,664 | 21,726 | 21,396 | 19,959 | 17,887 |
| Panhandle | 1,958 | 2,141 | 2,226 | 2,353 | 2,589 |
| Perryton | 7,903 | 7,810 | 7,991 | 7,607 | 7,774 |
| Quail | N/A | N/A | N/A | N/A | 33 |
| Quitaque | 586 | 601 | 696 | 506 | 432 |
| Samnorwood CDP | N/A | N/A | N/A | N/A | 39 |
| Sanford | N/A | 181 | 249 | 220 | 203 |
| Shamrock | 3,113 | 2,644 | 2,834 | 2,286 | 2,029 |
| Silverton | 1,098 | 1,026 | 918 | 794 | 771 |
| Skellytown | 967 | 716 | 899 | 674 | 610 |
| Spearman | 3,555 | 3,435 | 3,413 | 3,197 | 3,021 |
| Stinnett | 2,695 | 2,014 | 2,222 | 2,166 | 1,936 |
| Stratford | 1,380 | 2,139 | 1,917 | 1,781 | 1,991 |
| Sunray | 1,967 | 1,854 | 1,952 | 1,729 | 1,950 |
| Texhoma | 350 | 256 | 358 | 357 | 371 |
| Texline | 430 | 387 | 477 | 412 | 511 |
| Timbercreek Canyon | N/A | N/A | N/A | 274 | 406 |
| Tulia | 4,410 | 5,294 | 5,033 | 4,699 | 5,117 |
| Turkey | 813 | 680 | 644 | 514 | 494 |
| Vega | 658 | 839 | 900 | 827 | 936 |
| Wellington | 3,137 | 2,884 | 3,043 | 2,418 | 2,275 |
| Wheeler | 1,174 | 1,116 | 1,584 | 1,378 | 1,378 |
| White Deer | 1,057 | 1,092 | 1,210 | 1,125 | 1,060 |
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